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<title>The Navigator: Would you like fries with that?</title>
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<!--[if !gte mso 9]><!----><span class="mcnPreviewText" style="display:none; font-size:0px; line-height:0px; max-height:0px; max-width:0px; opacity:0; overflow:hidden; visibility:hidden; mso-hide:all;">The Type II diabetes drug Ozempic now generates approximately $15 billion in annual revenue for the company, with this figure continuing to grow...</span><!--<![endif]-->
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<table id="root" border="0" cellpadding="0" cellspacing="0" width="100%"><tbody data-block-id="25" class="mceWrapper"><tr><td align="center" valign="top" class="mceWrapperOuter"><!--[if (gte mso 9)|(IE)]><table align="center" border="0" cellspacing="0" cellpadding="0" width="660" style="width:660px;"><tr><td><![endif]--><table border="0" cellpadding="0" cellspacing="0" width="100%" style="max-width:660px" role="presentation"><tbody><tr><td style="background-color:#ffffff;background-position:center;background-repeat:no-repeat;background-size:cover" class="mceWrapperInner" valign="top"><table align="center" border="0" cellpadding="0" cellspacing="0" width="100%" role="presentation" data-block-id="24"><tbody><tr class="mceRow"><td style="background-position:center;background-repeat:no-repeat;background-size:cover" valign="top"><table border="0" cellpadding="0" cellspacing="0" width="100%" role="presentation"><tbody><tr><td style="padding-top:0;padding-bottom:0" class="mceColumn" data-block-id="-7" valign="top" colspan="12" width="100%"><table border="0" cellpadding="0" cellspacing="0" width="100%" role="presentation"><tbody><tr><td style="background-color:transparent;padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" class="mceBlockContainer" valign="top"><table align="center" border="0" cellpadding="0" cellspacing="0" width="100%" style="background-color:transparent;width:100%" role="presentation" class="mceDividerContainer" data-block-id="78"><tbody><tr><td style="min-width:100%;border-top:20px solid transparent" class="mceDividerBlock" valign="top"></td></tr></tbody></table></td></tr><tr><td style="padding-top:12px;padding-bottom:12px;padding-right:12px;padding-left:12px" class="mceBlockContainer" align="full" valign="top"><span class="mceImageBorder" style="border:0;vertical-align:top;margin:0"><img data-block-id="75" width="636" height="auto" style="width:636px;height:auto;max-width:1200px !important;display:block" alt="" src="https://mcusercontent.com/cdd951e6a7a08b835a0f38a3f/images/a86f839c-a053-ac69-09f0-15a92976560c.jpg" role="presentation" class="imageDropZone mceImage"></span></td></tr><tr><td style="background-color:transparent;padding-top:0;padding-bottom:5px;padding-right:24px;padding-left:24px" class="mceBlockContainer" valign="top"><table align="center" border="0" cellpadding="0" cellspacing="0" width="100%" style="background-color:transparent;width:100%" role="presentation" class="mceDividerContainer" data-block-id="48"><tbody><tr><td style="min-width:100%;border-top:2px solid #d0d0d0" class="mceDividerBlock" valign="top"></td></tr></tbody></table></td></tr><tr><td style="padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" valign="top"><table width="100%" style="border:0;border-collapse:separate"><tbody><tr><td style="padding-left:24px;padding-right:24px;padding-top:5px;padding-bottom:12px" class="mceTextBlockContainer"><div data-block-id="55" class="mceText" id="dataBlockId-55" style="width:100%"><p class="last-child"><span style="color:#4d4d4d;"><span style="font-size: 14px"><span style="font-family: 'Lato', 'Helvetica Neue', Helvetica, Arial, sans-serif">Edition 066 | </span>July 2024</span></span></p></div></td></tr></tbody></table></td></tr><tr><td style="padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" class="mceBlockContainer" align="left" valign="top"><span class="mceImageBorder" style="border:0;vertical-align:top;margin:0"><img data-block-id="36" width="660" height="auto" style="width:660px;height:auto;max-width:1800px !important;display:block" alt="" src="https://mcusercontent.com/cdd951e6a7a08b835a0f38a3f/images/1be180ad-8a18-4b8d-fb89-30adc0bc0a48.jpg" role="presentation" class="imageDropZone mceImage"></span></td></tr><tr><td style="padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" valign="top"><table width="100%" style="border:0;border-collapse:separate"><tbody><tr><td style="padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px" class="mceTextBlockContainer"><div data-block-id="85" class="mceText" id="dataBlockId-85" style="width:100%"><h4 class="last-child">Every now and again something new comes along which changes the world. Until recently, Novo Nordisk, a 100-year-old Danish pharmaceutical company and the original manufacturer of insulin for diabetes treatment, would have been unfamiliar to most people.</h4></div></td></tr></tbody></table></td></tr><tr><td style="padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" valign="top"><table width="100%" style="border:0;border-collapse:separate"><tbody><tr><td style="padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px" class="mceTextBlockContainer"><div data-block-id="86" class="mceText" id="dataBlockId-86" style="width:100%"><p class="last-child">They are still at it. Launched in 2017, the Type II diabetes drug Ozempic now generates approximately $15 billion in annual revenue for the company, with this figure continuing to grow robustly. The key ingredient in the drug, called a semaglutide, mimics a natural hormone found in the body to control blood-sugar levels, assisting those with Type 2 diabetes (T2D) to manage their condition long term.</p></div></td></tr></tbody></table></td></tr><tr><td style="padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0" class="mceBlockContainer" align="center" valign="top"><span class="mceImageBorder" style="border:0;vertical-align:top;margin:0"><img data-block-id="87" width="564" height="auto" style="width:564px;height:auto;max-width:1000px !important;display:block" alt="" src="https://mcusercontent.com/cdd951e6a7a08b835a0f38a3f/images/c2038182-ed7f-970a-612f-07771b46a5b8.jpeg" role="presentation" class="imageDropZone mceImage"></span></td></tr><tr><td style="padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" valign="top"><table width="100%" style="border:0;border-collapse:separate"><tbody><tr><td style="padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px" class="mceTextBlockContainer"><div data-block-id="74" class="mceText" id="dataBlockId-74" style="width:100%"><p>But sometimes life throws you a super-size deal. In the case of Ozempic, there was an unexpected side effect: significant and sustained weight loss by those on the medication. From a survey of almost 2000 adults categorized as ‘obese’<sup>1</sup>, they found that on average the candidates lost 15% of their body weight over a period of 68 weeks. This discovery paved the way for Ozempic the T2D drug to be rebranded as Wegovy the weight loss drug. The drugs act as an appetite suppressant. The benefits are now proven and Ozempic/Wegovy users are likely to maintain healthier weights and are at lower risk of cardiovascular disease.</p><p><br></p><p class="last-child">It is a huge potential market, and currently there are only two real participants – Novo and Eli Lily. The chart below highlights the untapped potential of diabetes as well as obesity care where hundreds of millions of people are currently not treated globally. The instance of diabetes and obesity is also growing, providing Novo with tailwinds in the volume of people they can support.</p></div></td></tr></tbody></table></td></tr><tr><td style="padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0" class="mceBlockContainer" align="center" valign="top"><span class="mceImageBorder" style="border:0;vertical-align:top;margin:0"><img data-block-id="79" width="564" height="auto" style="width:564px;height:auto;max-width:1384px !important;display:block" alt="" src="https://mcusercontent.com/cdd951e6a7a08b835a0f38a3f/images/76cc0806-d41d-0ea5-aefc-7b300f6d5cca.jpg" role="presentation" class="imageDropZone mceImage"></span></td></tr><tr><td style="padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" valign="top"><table width="100%" style="border:0;border-collapse:separate"><tbody><tr><td style="padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px" class="mceTextBlockContainer"><div data-block-id="80" class="mceText" id="dataBlockId-80" style="width:100%"><p>The implications arising from the success of Ozempic and Wegovy are broader than you may imagine and impact a wide range of industries.</p><ul><li><p>Food volumes for individuals on the drug drop dramatically, impacting sales expectations for the large food retailers such as Walmart.</p></li><li><p>Fast food companies are at risk as individuals have no appetite for these forms of meals. Equally so for sugar-based drinks. Alcohol drops in line with a suppressed appetite and less frequent visits to restaurants and general socializing. Alcohol distributors such as Diageo adapt by moving away from volume brands to higher profitability premium brands which are more Ozempic friendly.</p></li><li><p>The ‘snack’ industry is well positioned however, as larger meals are replaced with smaller, more frequent, high protein snacks. Product manufacturers are starting to change their product mix to adapt.</p></li><li><p>Fashion retailers are prioritizing sportswear as individuals on the weight loss medication quickly replace their wardrobes. Make-up brands are positioning to support “Ozempic Face” – helping mask the sunken cheeks and ageing skin which can occur on the medication.</p></li><li><p>Life expectancy is also longer, impacting how life assurers price morbidity risk.</p></li></ul><p><br></p><p>The far-reaching impact on peoples’ lives is very significant and companies who don’t adapt will struggle. Take Weight Watchers for example: trading at almost $100 per share in 2018, it has fallen to $1.50 since then in the wake of the Ozempic success. Why go on a diet if you can simply take an injection?</p><p><br></p><h4>Obesity is a serious chronic disease with a large unmet medical need</h4><h4 class="last-child">that impacts many aspects of a patient’s life</h4></div></td></tr></tbody></table></td></tr><tr><td style="padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0" class="mceBlockContainer" align="center" valign="top"><span class="mceImageBorder" style="border:0;vertical-align:top;margin:0"><img data-block-id="88" width="564" height="auto" style="width:564px;height:auto;max-width:1384px !important;display:block" alt="" src="https://mcusercontent.com/cdd951e6a7a08b835a0f38a3f/images/67eab4dc-e199-49bf-56dc-dd65ce6e7878.jpg" role="presentation" class="imageDropZone mceImage"></span></td></tr><tr><td style="padding-top:0;padding-bottom:0;padding-right:0;padding-left:0" valign="top"><table width="100%" style="border:0;border-collapse:separate"><tbody><tr><td style="padding-left:24px;padding-right:24px;padding-top:12px;padding-bottom:12px" class="mceTextBlockContainer"><div data-block-id="89" class="mceText" id="dataBlockId-89" style="width:100%"><p><span style="font-size: 12px">Source: Novo Nordisk; World Obesity Atlas 2023</span></p><p> </p><p>Investors in Novo Nordisk and Eli Lily have done very well of late. Novo doesn’t pay much in the way of dividends (an annual yield of just over 1%), but the share price is up 80% over the past year, and up 40% per year, each year for the past 5 years. Novo is now the largest company in Europe, and its market value is greater than the whole GDP of Denmark.</p><p><br></p><p>Investors think there is more to come, which is why the share is still trading on a valuation of 49x the past years earnings. So where does this fit into our lives? The good news is that Novo Nordisk has been a significant holding in the BNY Mellon Long Term Global Equity Fund managed by Walter Scott & Partners in Edinburgh<sup>2</sup>. This is a Tier 1 rated fund used in our clients' Global Equity portfolios.</p><p><br></p><p>We use funds like BNY to access what we could term “high quality” businesses. These are businesses like Novo Nordisk, which have immensely strong foundations to put themselves in position to be at the forefront of new product innovation such as Ozempic. Novo never invented the chemical compound used in the drug, but had the long-term vision, the deep pockets, the Foundation based ownership structure and the dedicated group of scientists they could allocate to take a new innovation and turn it into a commercially viable product.</p><p><br></p><p>The trouble with high-quality businesses like Novo Nordisk is that you rarely pick them up at a bargain price. The lowest Price: Earnings multiple they have traded at over the past three decades is around 15x (1994) and they have averaged 27x over this time. This means they need to deliver on earnings growth above the market to justify this lofty price premium. And they have done just that, averaging 17% earnings growth per year for thirty years, double that of the average company.</p><p><br></p><p>It may seem obvious in retrospect, as does a Tesla or an NVIDIA which have similarly delivered exceptional returns. The difference in this instance is that Novo Nordisk is a hundred-year-old company growing at the rate of a start-up! While this is quite unusual it shouldn’t be a surprise given the platform, they have to develop products like Ozempic and Wegovy which provides them with a substantial advantage. Would you back Weightwatchers to build out their Ozempic competitor?<sup>3</sup> Or Novo Nordisk, with its 64,000 employees scattered across the globe developing new medicines for the past century?</p><p><br></p><p>Ozempic is a new drug with a wide impact that will be felt for years to come – for the better. We need to back companies like Novo to identify and develop them, and we need to back companies like Walter Scott to see the opportunity, do the homework and pay up for those companies that will outpace the broad market, and which justify the premium price tag.</p><p><br></p><p><span style="font-size: 12px">[1] Based on a Body Mass Index (BMI) of 30 or greater</span></p><p><span style="font-size: 12px">[2] It is currently ~4.5% of the funds holdings, from an initial weighting of 2.5%. Walter Scott has been investing in Novo Nordisk for nearly two decades.</span></p><p><span style="font-size: 12px">[3] They are doing this interestingly, but one feels it may be too little, too late.</span></p><p class="last-child"><br></p></div></td></tr></tbody></table></td></tr><tr><td style="padding-top:12px;padding-bottom:12px;padding-right:0;padding-left:0" class="mceBlockContainer" align="center" valign="top"><span class="mceImageBorder" style="border:0;vertical-align:top;margin:0"><img data-block-id="90" width="564" height="auto" style="width:564px;height:auto;max-width:1384px !important;display:block" alt="" src="https://mcusercontent.com/cdd951e6a7a08b835a0f38a3f/images/7ce1ea35-b062-ba67-48f1-336f132fe27e.jpg" role="presentation" class="imageDropZone mceImage"></span></td></tr><tr><td style="background-color:#f4f4f4;padding-top:8px;padding-bottom:8px;padding-right:8px;padding-left:8px" class="mceLayoutContainer" valign="top"><table align="center" border="0" cellpadding="0" 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